39
genes

The Wellness Review

Genetic variations can indicate the best diet and exercise routine for you. A DNA4Life wellness review eliminates the struggle associated with weight loss by analyzing your unique genetic makeup and providing customized action items. By having this data in hand, you will know the types of exercise and diet plans that will maximize your weight loss results. The more genetic variations found in the wellness review, the more actionable items are provided for enhanced results.

wellness review

Nutrition + Genes

FTO

Certain variants of this gene are associated with increased obesity and an influence on appetite regulation in a study of nearly 5,000 people. Certain genotypes are associated with difficulty feeling full after eating, thus, people with those genotypes tend to overeat and gain weight.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

DRD2

This gene codes for a type of dopamine receptor that plays an important role in the reward system of the brain. It influences how the brain responds to dopamine, a neurotransmitter relating to rewards and behavior. Certain variants of this gene may lead to increased behaviors that provide immediate rewards, like smoking or overeating, and is also related to addictive behaviors.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

FTO

Certain variants of this gene are associated with increased obesity and an influence on appetite regulation in a study of nearly 5,000 people. Certain genotypes are associated with difficulty feeling full after eating, thus, people with those genotypes tend to overeat and gain weight.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

DRD2

This gene codes for a type of dopamine receptor that plays an important role in the reward system of the brain. It influences how the brain responds to dopamine, a neurotransmitter relating to rewards and behavior. Certain variants of this gene may lead to increased behaviors that provide immediate rewards, like smoking or overeating, and is also related to addictive behaviors.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

Fitness + Genes

MC4R

A variant of this gene was associated with increased waist circumference, increased BMI, and insulin resistance in a study of over 13,000 people.

LIPC

Certain variants of this gene have been asssociated with enhanced benefit from endurance training

SEC16B

A variant of this gene was associated with a greatly increased risk of obesity in children and an increased risk of obesity in adults.

TMEM18

A variant of this gene was associated with an increased risk of extreme obesity in children and an increased risk of obesity in adults.

INSIG2

A variant of this gene was associated with obesity in adults and children, especially in women. In men, this variant has been associated with increased body fat when strength training.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

ADIPOQ

Certain variants of this gene are associated with increased benefit from eating monounsaturated fats and may also protect against regaining weight after dieting.

ALDH2

This gene codes for the enzyme that metabolizes alcohol. Certain variants of this gene result in a decreased ability to metabolize alcohol, thus increasing the risk of toxicity when consuming alcohol.

APOA2

A large study of over 3,000 people from 3 independent populations found a gene-diet interaction associated with increased BMI (6.2%) and obesity. This gene is associated with extremely efficient fat processing. People with certain associated genotypes should avoid saturated fats.

BCMO1

This gene has been associated with converting beta-carotene into Vitamin A so it can be used by the body. People with some genotypes will benefit from a diet rich in beta-carotene (carrots, pumpkin, sweet potato, spinach) and while people with other genotypes will receive more benefit from a multivitamin containing Vitamin A.

COMT

This gene is involved in dopamine, serotonin, and noradrenaline production in the brain. These neurotransmitters are, in turn, related to emotional patterns, which can affect eating behaviors. A variant of this gene is associated with obesity, type 2 diabetes, and impaired glucose tolerance.

CYP1A2

This gene is associated with the ability to metabolize caffeine and related chemicals.

FUT2

Certain variants of this gene have been associated with decreased levels of Vitamin B12, an important part of brain function, glucose metabolism, and heart health.

GC

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for overall wellness and health.

INTERGENIC

In a study of nearly 4,000 people, a variant of this gene was associated with decreased levels of Vitamin E. Though there is no consensus about recommended levels of Vitamin E, many experts recommend supplementation, claiming improved metabolism, boosted immune response, and less risk of chronic disease.

KCDT10

Certain variants of this gene are linked to increased levels of low-density lipoprotein (LDL), or bad cholesterol, and decreased levels of of high-density lipoprotein (HDL), or good cholesterol, when following a high-carbohydrate diet.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

MMAB

Certain variants of this gene are linked to increased levels of low-density lipoprotein (LDL), or bad cholesterol, and decreased levels of of high-density lipoprotein (HDL), or good cholesterol, when following a high-carbohydrate diet.

MTHFR

Certain variants of this gene have been associated with impaired function of MTHFR, an enzyme that converts dietary folate into its active form. Impaired MTHFR function may interrupt necessary biochemical pathways by reducing folate metabolism.

NBPF3

Certain variants of this gene have been associated with decreased levels of Vitamin B6, an important part of brain function, glucose metabolism, and heart health.

NEARCYP2R1

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for overall wellness and health.

NEARDHCR7

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for skeletal health.

PPARG

Certain variants of this gene are associated with an increased risk of atherosclerosis and obesity when eating a high fat diet.

SLCA2

This gene has been associated with a higher level of sugar intake, possibly due to the way the brain senses glucose levels.

TAS2R38

This gene has been associated with a diminishment in taste perception that allows disinhibition, or the inability to stop eating. In a study of over 700 people, it was linked to over eating behavior for women, but not for men, for certain genotypes.

TAS2R38

This gene is associated with the ability to detect bitter tastes. Sensitivity to bitter taste has long been known to have a genetic component with evolutionary and anthropological implications. Many poisonous things taste bitter, and being able to taste and avoid these things is an evolutionary advantage.

ACTN3

This gene has been associated with the ability of the body to use alpha-actinin-3 protein, a protein that enhances fast-twitch in muscle fibers. This means that the body can generate force at a high velocity; for example, male and female worldclass sprinters have significantly higher frequencies of one of these genotypes.

BDNF

This gene was associated with increased risk of obesity in a meta-analysis of 15 studies. Particular variants of this gene are associated with an increased risk for depression, resulting from altered neurotransmitter function.

ETV5

A variant of this gene has been associated with an increased risk of obesity as an adult.

FAIM2

A variant of this gene was associated with increased risk of obesity in a meta-analysis of other similar genes.

FTO

A variant of this gene has been associated with early onset of obesity in adolescents and children that continued into adulthood.

HTR2A

A variant of this gene was associated with obesity in adults and children, especially in women. In men, this variant has been associated with increased body fat when strength training

LEP

Certain variants of this gene are associated with risk of significant obesity, especially among those with Pacific Islander heritage. These variants are also associated with increased weight gain in children who take risperidone (used to treat schizophrenia or bipolar disorder).

LEPR

This gene influences resting metabolic rate. One major contributor to weight gain and weight loss is the metabolic rate of individuals. People with a higher resting metabolism rate will naturally burn more calories than others doing the same basic activities. This leads to lower average weight and slower weight gain.

LIPC

Certain variants of this gene have been associated with enhanced benefit from endurance training.

MC4R

A variant of this gene was associated with increased waist circumference, increased BMI, and insulin resistance in a study of over 13,000 people.

NCR3_ AIF1

A variant of this gene is associated with extreme obesity in childhood, and is associated with obesity in adults

NEARKCTD15

In a large study of over 16,000 people of European descent, this gene was found to be associated with increased risk of obesity. This finding was confirmed in another large study involving people of Chinese descent. Current thinking is that this gene acts as a transcription factor, a piece of DNA that controls how other important genes are processed by the body.

NERG1

A variant of this gene is nearly always found in children who experience extreme obesity in childhood, and is associated with obesity in adults. Little is known about this gene, but it is thought to be related to neurological processes that take place in the hypothalamus, such as energy balance and appetite, that contribute to obesity.

PCSK1_2

An increased risk of obesity was found to be associated with this gene in a study that encompassed over 13,000 individuals of European descent. The study also postulated that this gene affects the way protein is processed.

PPARD

In a study of over 700 subjects, variants of this gene were linked to an increased beneficial impact on HDL levels as a result of endurance exercise.

SEC16B

A variant of this gene was associated with a greatly increased risk of obesity in children and an increased risk of obesity in adults.

SH2B1

A variant of this gene was associated with increased risk of obesity in the same study that identified many other similar genes.

TMEM18

A variant of this gene was associated with an increased risk of extreme obesity in children and an increased risk of obesity in adults.

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Benefits of a Wellness Review

  • Provides information on how 39 of your genes can impact your health and wellness
  • Offers dietary and lifestyle action items that can enhance or negate genetic tendencies
  • Gives exercise recommendations based on your unique genetic makeup
  • Supplies you with a more scientific and accurate way for mineral and vitamin supplement product selection than the current “one-size-fits-all” approach

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7

Only One You. Find Out What Makes You So Unique.

A piano has 88 keys. Each one of them is different. Each key represents a different musical note. When blended together, you experience the richness and fullness of what music can offer. 

The same holds true for you. You are unique. There is no one else on this earth like you. Understanding what makes you different can significantly impact your life. This is where DNA4Life can help you. 

From a genetic snapshot of your health and wellness to reports on your skins vitality, we unlock the answers to what makes you so unique. Like the music produced by the 88 keys on the piano, DNA4Life holds the key to discover what makes you so different.

One Size Does Not Fit
All. Uncover Your Difference.

STEP ONE: ORDER

Start by ordering your DNA4Life Report online. We will send you the package.You will receive an email with instructions on:

  • How you will be notified that your report is ready.
  • How to retrieve your report when it is ready.

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STEP TWO: COLLECT

Our DNA Sample Collection Package includes detailed instructions on how to provide your DNA sample. Gently rub the DNA collection swabs on the inside of your cheek, and place the swabs back inside the Envelope provided.

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STEP THREE: SEND

Place the Sample Collection Envelope in the postage prepaid and pre-addressed return envelope and drop it in the United States mail back to us. It’s that easy!

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What Is Your DNA Trying To Tell You?

• Optimize Your Skin’s Health & Vitality
• Improve Your Diet, Nutrition, & Exercise Routine