What Is Your DNA Trying To Tell You?

• Optimize Your Skin’s Health & Vitality
• Improve Your Diet, Nutrition, & Exercise Routine

7

Only One You. Find Out What Makes You So Unique.

A piano has 88 keys. Each one of them is different. Each key represents a different musical note. When blended together, you experience the richness and fullness of what music can offer. 

The same holds true for you. You are unique. There is no one else on this earth like you. Understanding what makes you different can significantly impact your life. This is where DNA4Life can help you. 

From a genetic snapshot of your health and wellness to reports on your skins vitality, we unlock the answers to what makes you so unique. Like the music produced by the 88 keys on the piano, DNA4Life holds the key to discover what makes you so different.

39
genes

The Wellness Review

wellness review

Nutrition + Genes

FTO

Certain variants of this gene are associated with increased obesity and an influence on appetite regulation in a study of nearly 5,000 people. Certain genotypes are associated with difficulty feeling full after eating, thus, people with those genotypes tend to overeat and gain weight.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

DRD2

This gene codes for a type of dopamine receptor that plays an important role in the reward system of the brain. It influences how the brain responds to dopamine, a neurotransmitter relating to rewards and behavior. Certain variants of this gene may lead to increased behaviors that provide immediate rewards, like smoking or overeating, and is also related to addictive behaviors.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

FTO

Certain variants of this gene are associated with increased obesity and an influence on appetite regulation in a study of nearly 5,000 people. Certain genotypes are associated with difficulty feeling full after eating, thus, people with those genotypes tend to overeat and gain weight.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

DRD2

This gene codes for a type of dopamine receptor that plays an important role in the reward system of the brain. It influences how the brain responds to dopamine, a neurotransmitter relating to rewards and behavior. Certain variants of this gene may lead to increased behaviors that provide immediate rewards, like smoking or overeating, and is also related to addictive behaviors.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

Fitness + Genes

MC4R

A variant of this gene was associated with increased waist circumference, increased BMI, and insulin resistance in a study of over 13,000 people.

LIPC

Certain variants of this gene have been asssociated with enhanced benefit from endurance training

SEC16B

A variant of this gene was associated with a greatly increased risk of obesity in children and an increased risk of obesity in adults.

TMEM18

A variant of this gene was associated with an increased risk of extreme obesity in children and an increased risk of obesity in adults.

INSIG2

A variant of this gene was associated with obesity in adults and children, especially in women. In men, this variant has been associated with increased body fat when strength training.

ADIPOQ

This gene was found to be associated with adiponectin levels in a study with over 2,000 participants. Adiponectin levels are inversely related to obesity levels and some types of cancer. Adiponectin is a hormone produced by the body to help control fat metabolism and improve overall health. Having higher blood levels of adiponectin increases your ability to process fat. The control of this hormone is partially controlled by this gene.

ADIPOQ

Certain variants of this gene are associated with increased benefit from eating monounsaturated fats and may also protect against regaining weight after dieting.

ALDH2

This gene codes for the enzyme that metabolizes alcohol. Certain variants of this gene result in a decreased ability to metabolize alcohol, thus increasing the risk of toxicity when consuming alcohol.

APOA2

A large study of over 3,000 people from 3 independent populations found a gene-diet interaction associated with increased BMI (6.2%) and obesity. This gene is associated with extremely efficient fat processing. People with certain associated genotypes should avoid saturated fats.

BCMO1

This gene has been associated with converting beta-carotene into Vitamin A so it can be used by the body. People with some genotypes will benefit from a diet rich in beta-carotene (carrots, pumpkin, sweet potato, spinach) and while people with other genotypes will receive more benefit from a multivitamin containing Vitamin A.

COMT

This gene is involved in dopamine, serotonin, and noradrenaline production in the brain. These neurotransmitters are, in turn, related to emotional patterns, which can affect eating behaviors. A variant of this gene is associated with obesity, type 2 diabetes, and impaired glucose tolerance.

CYP1A2

This gene is associated with the ability to metabolize caffeine and related chemicals.

FUT2

Certain variants of this gene have been associated with decreased levels of Vitamin B12, an important part of brain function, glucose metabolism, and heart health.

GC

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for overall wellness and health.

INTERGENIC

In a study of nearly 4,000 people, a variant of this gene was associated with decreased levels of Vitamin E. Though there is no consensus about recommended levels of Vitamin E, many experts recommend supplementation, claiming improved metabolism, boosted immune response, and less risk of chronic disease.

KCDT10

Certain variants of this gene are linked to increased levels of low-density lipoprotein (LDL), or bad cholesterol, and decreased levels of of high-density lipoprotein (HDL), or good cholesterol, when following a high-carbohydrate diet.

LIPC

This gene impacts the amount of high-density lipoprotein (HDL) or good cholesterol produced by the body. People with low HDL levels are at increased risk of cardiovascular disease. Certain variants of this gene are associated with increased HDL levels when combined with a moderate dietary fat intake.

MCM6

A study involving four different populations found a very strong correlation between certain variants of this gene and lactose intolerance. Lactose intolerance, is the inability to digest milk products containing lactose

MMAB

Certain variants of this gene are linked to increased levels of low-density lipoprotein (LDL), or bad cholesterol, and decreased levels of of high-density lipoprotein (HDL), or good cholesterol, when following a high-carbohydrate diet.

MTHFR

Certain variants of this gene have been associated with impaired function of MTHFR, an enzyme that converts dietary folate into its active form. Impaired MTHFR function may interrupt necessary biochemical pathways by reducing folate metabolism.

NBPF3

Certain variants of this gene have been associated with decreased levels of Vitamin B6, an important part of brain function, glucose metabolism, and heart health.

NEARCYP2R1

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for overall wellness and health.

NEARDHCR7

In a study of nearly 34,000 people of European descent, this gene was associated with insufficiency of Vitamin D, an important vitamin for skeletal health.

PPARG

Certain variants of this gene are associated with an increased risk of atherosclerosis and obesity when eating a high fat diet.

SLCA2

This gene has been associated with a higher level of sugar intake, possibly due to the way the brain senses glucose levels.

TAS2R38

This gene has been associated with a diminishment in taste perception that allows disinhibition, or the inability to stop eating. In a study of over 700 people, it was linked to over eating behavior for women, but not for men, for certain genotypes.

TAS2R38

This gene is associated with the ability to detect bitter tastes. Sensitivity to bitter taste has long been known to have a genetic component with evolutionary and anthropological implications. Many poisonous things taste bitter, and being able to taste and avoid these things is an evolutionary advantage.

ACTN3

This gene has been associated with the ability of the body to use alpha-actinin-3 protein, a protein that enhances fast-twitch in muscle fibers. This means that the body can generate force at a high velocity; for example, male and female worldclass sprinters have significantly higher frequencies of one of these genotypes.

BDNF

This gene was associated with increased risk of obesity in a meta-analysis of 15 studies. Particular variants of this gene are associated with an increased risk for depression, resulting from altered neurotransmitter function.

ETV5

A variant of this gene has been associated with an increased risk of obesity as an adult.

FAIM2

A variant of this gene was associated with increased risk of obesity in a meta-analysis of other similar genes.

FTO

A variant of this gene has been associated with early onset of obesity in adolescents and children that continued into adulthood.

HTR2A

A variant of this gene was associated with obesity in adults and children, especially in women. In men, this variant has been associated with increased body fat when strength training

LEP

Certain variants of this gene are associated with risk of significant obesity, especially among those with Pacific Islander heritage. These variants are also associated with increased weight gain in children who take risperidone (used to treat schizophrenia or bipolar disorder).

LEPR

This gene influences resting metabolic rate. One major contributor to weight gain and weight loss is the metabolic rate of individuals. People with a higher resting metabolism rate will naturally burn more calories than others doing the same basic activities. This leads to lower average weight and slower weight gain.

LIPC

Certain variants of this gene have been associated with enhanced benefit from endurance training.

MC4R

A variant of this gene was associated with increased waist circumference, increased BMI, and insulin resistance in a study of over 13,000 people.

NCR3_ AIF1

A variant of this gene is associated with extreme obesity in childhood, and is associated with obesity in adults

NEARKCTD15

In a large study of over 16,000 people of European descent, this gene was found to be associated with increased risk of obesity. This finding was confirmed in another large study involving people of Chinese descent. Current thinking is that this gene acts as a transcription factor, a piece of DNA that controls how other important genes are processed by the body.

NERG1

A variant of this gene is nearly always found in children who experience extreme obesity in childhood, and is associated with obesity in adults. Little is known about this gene, but it is thought to be related to neurological processes that take place in the hypothalamus, such as energy balance and appetite, that contribute to obesity.

PCSK1_2

An increased risk of obesity was found to be associated with this gene in a study that encompassed over 13,000 individuals of European descent. The study also postulated that this gene affects the way protein is processed.

PPARD

In a study of over 700 subjects, variants of this gene were linked to an increased beneficial impact on HDL levels as a result of endurance exercise.

SEC16B

A variant of this gene was associated with a greatly increased risk of obesity in children and an increased risk of obesity in adults.

SH2B1

A variant of this gene was associated with increased risk of obesity in the same study that identified many other similar genes.

TMEM18

A variant of this gene was associated with an increased risk of extreme obesity in children and an increased risk of obesity in adults.

9
genes

The Skin Care Report

skin care (1)

Antioxidant + Genes

NQO1

NAD(P)H dehydrogenase [quinone] 1 is the enzyme encoded by the gene, NQO1, that generates and maintains the active form of Coenzyme Q10 (CoQ10) in mitochondrial membrane systems and liposomes, thereby promoting CoQ10’s antioxidant activity. CoQ10 is an antioxidant made in the human body that is needed for basic cell function. CoQ10 levels decrease with age. CoQ10 has been also identified as a modulator of gene expression, inflammatory processes, and programmed cell death (apoptosis).

SOD2

Superoxide Dismutase II (SOD2) is the enzyme encoded by the gene, SOD2, and converts superoxide, an extremely toxic byproduct of cellular respiration, into hydrogen peroxide and oxygen gas. The hydrogen peroxide is further broken down into water. These actions of SOD2 reduce free-radicals and provide protection against cell death, oxidative stress, ionizing radiation, and inflammation.

NFE2L2

Nuclear factor erythroid 2-related factor 2 (Nrf2) is encoded by the gene, NFE2L2. Under non-stressful conditions, Nrf2 is regulated by proteins in the cell that degrade it quickly. Under oxidative stress, Nrf2 is not destroyed and migrates to the cell nucleus and binds to DNA. This binding of Nrf2 to promoter DNA initiates transcription of antioxidative genes and the production cytoprotective proteins. These cytoprotective proteins include NAD(P)H dehydrogenase [quinone] 1, which is involved in CoQ10 metabolism.

NFE2L2

Nuclear factor erythroid 2-related factor 2 (Nrf2) is encoded by the gene, NFE2L2. Under non-stressful conditions, Nrf2 is regulated by proteins in the cell that degrade it quickly. Under oxidative stress, Nrf2 is not destroyed and migrates to the cell nucleus and binds to DNA. This binding of Nrf2 to promoter DNA initiates transcription of antioxidative genes and the production cytoprotective proteins. These cytoprotective proteins include NAD(P)H dehydrogenase [quinone] 1, which is involved in CoQ10 metabolism.

CAT

Catalase is the enzyme encoded by the gene, CAT, and is very abundant in all types of tissues. It converts hydrogen peroxide into water and oxygen, thereby it is an important enzyme in protecting the cell from oxidative damage. Hydrogen peroxide is a harmful byproduct of many normal metabolic processes, and to prevent damage to cells and tissues, it must be quickly converted into water and oxygen. Catalase is an anti-oxidant workhorse with one of the highest turnover numbers of all enzymes; one catalase molecule can convert 5 million hydrogen peroxide molecules into water and oxygen each second. Low levels of catalase may play a role in the graying process of human hair, for if catalase levels decline, hydrogen peroxide cannot be broken down as well, allowing the hydrogen peroxide to bleach the hair before it can leave the hair follicle.

GPX1

Glutathione Peroxidase 1 is the enzyme encoded by the gene, GPX1. This enzyme plays a major role in protecting the cells against damage from oxygen radicals. It does this by reducing lipid hydroperoxides to their corresponding alcohols, and to reducing hydrogen peroxide to water. Lipid hydroperoxides are the result of the oxidative degradation of lipids, in which free radicals “steal” electrons from the lipids in cell membranes, resulting in damage to the cell membrane. Whenever, a free radical steals an electron from a lipid, it radicalizes the lipid and the cycle is continued, also known as a free radical chain reaction mechanism. This chain reaction is terminated by anti-oxidant molecules and enzymes that lock up free radicals, thereby protecting the cell membrane. If not terminated fast enough, there will be damage to the cell membranes, and since the end products of lipid peroxidation are reactive aldehydes that damage DNA, these end products are mutagenic and carcinogenic. Antioxidants that terminate this lipid peroxidation chain reaction include Vitamin E, Vitamin C, and the anti-oxidizing enzymes superoxide dismutase, catalase, and glutathione peroxidase 1.

NQO1

NAD(P)H dehydrogenase [quinone] 1 is the enzyme encoded by the gene, NQO1, that generates and maintains the active form of Coenzyme Q10 (CoQ10) in mitochondrial membrane systems and liposomes, thereby promoting CoQ10’s antioxidant activity. CoQ10 is an antioxidant made in the human body that is needed for basic cell function. CoQ10 levels decrease with age. CoQ10 has been also identified as a modulator of gene expression, inflammatory processes, and programmed cell death (apoptosis).

SOD2

Superoxide Dismutase II (SOD2) is the enzyme encoded by the gene, SOD2, and converts superoxide, an extremely toxic byproduct of cellular respiration, into hydrogen peroxide and oxygen gas. The hydrogen peroxide is further broken down into water. These actions of SOD2 reduce free-radicals and provide protection against cell death, oxidative stress, ionizing radiation, and inflammation.

NFE2L2

Nuclear factor erythroid 2-related factor 2 (Nrf2) is encoded by the gene, NFE2L2. Under non-stressful conditions, Nrf2 is regulated by proteins in the cell that degrade it quickly. Under oxidative stress, Nrf2 is not destroyed and migrates to the cell nucleus and binds to DNA. This binding of Nrf2 to promoter DNA initiates transcription of antioxidative genes and the production cytoprotective proteins. These cytoprotective proteins include NAD(P)H dehydrogenase [quinone] 1, which is involved in CoQ10 metabolism.

NFE2L2

Nuclear factor erythroid 2-related factor 2 (Nrf2) is encoded by the gene, NFE2L2. Under non-stressful conditions, Nrf2 is regulated by proteins in the cell that degrade it quickly. Under oxidative stress, Nrf2 is not destroyed and migrates to the cell nucleus and binds to DNA. This binding of Nrf2 to promoter DNA initiates transcription of antioxidative genes and the production cytoprotective proteins. These cytoprotective proteins include NAD(P)H dehydrogenase [quinone] 1, which is involved in CoQ10 metabolism.

CAT

Catalase is the enzyme encoded by the gene, CAT, and is very abundant in all types of tissues. It converts hydrogen peroxide into water and oxygen, thereby it is an important enzyme in protecting the cell from oxidative damage. Hydrogen peroxide is a harmful byproduct of many normal metabolic processes, and to prevent damage to cells and tissues, it must be quickly converted into water and oxygen. Catalase is an anti-oxidant workhorse with one of the highest turnover numbers of all enzymes; one catalase molecule can convert 5 million hydrogen peroxide molecules into water and oxygen each second. Low levels of catalase may play a role in the graying process of human hair, for if catalase levels decline, hydrogen peroxide cannot be broken down as well, allowing the hydrogen peroxide to bleach the hair before it can leave the hair follicle.

GPX1

Glutathione Peroxidase 1 is the enzyme encoded by the gene, GPX1. This enzyme plays a major role in protecting the cells against damage from oxygen radicals. It does this by reducing lipid hydroperoxides to their corresponding alcohols, and to reducing hydrogen peroxide to water. Lipid hydroperoxides are the result of the oxidative degradation of lipids, in which free radicals “steal” electrons from the lipids in cell membranes, resulting in damage to the cell membrane. Whenever, a free radical steals an electron from a lipid, it radicalizes the lipid and the cycle is continued, also known as a free radical chain reaction mechanism. This chain reaction is terminated by anti-oxidant molecules and enzymes that lock up free radicals, thereby protecting the cell membrane. If not terminated fast enough, there will be damage to the cell membranes, and since the end products of lipid peroxidation are reactive aldehydes that damage DNA, these end products are mutagenic and carcinogenic. Antioxidants that terminate this lipid peroxidation chain reaction include Vitamin E, Vitamin C, and the anti-oxidizing enzymes superoxide dismutase, catalase, and glutathione peroxidase 1.

Skin Elasticity + Genes

MMP1

Matrix Metalloproteinase-1 (MMP1) is an enzyme, encoded by the gene, MMP1, that breaks down collagen. Collagen is the main structural protein of connective tissue. Collagen is vital for skin elasticity, giving skin its firmness, suppleness, and plays a role in the constant renewal of skin cells. Over activity of MMP1 increases collagen degradation, resulting in loss of skin elasticity (firmness, suppleness, and skin cell renewal), increased wrinkling, and skin sagging. An insertion mutation in the promoter region of MMP1 results in increased expression of the enzyme, and over activity of MMP1.

IL6

Interleukin-6 (IL-6) is a pro-inflammatory cytokine, encoded by the gene, IL6. IL-6 is secreted by immune system cells and adipocytes (i.e. fat cells) to stimulate an immune response, such as occurs from tissue damage, leading to inflammation. IL-6 signaling following tissue damage creates a pro-inflammatory response, including the production of the inflammatory C-reactive protein. C-reactive protein contributes to inflammation-induced tissue damage by stimulating the white blood cells to “eat” dead cells and cellular debris. Thus, over expression of IL-6 leads to increased susceptibility to tissue inflammation and subsequent skin damage.

MMP3

Matrix Metalloproteinase-3 (MMP3) is an enzyme, encoded by the gene, MMP3, that breaks down extracellular matrix proteins. Matrix metalloproteinases (MMPs) are a family of enzymes that degrade the components of the extracellular matrix. MMP3 degrades multiple extracellular matrix proteins, and additionally activates other MMPs that synergistically regulate the integrity of the extracellular matrix. MMP-3 expression is increased in response to stimuli including growth factors and cytokines. Extracellular matrix proteins are secreted by cells in order to provide structural and biochemical support to adjacent cells. The extracellular matrix regulates a cell’s dynamic behavior, serving many functions such as providing support, segregating tissues from one another, and regulating intercellular communication. Also importantly, the extracellular matrix accumulates and stores numerous cellular growth factors. Under appropriate physiological conditions, the extracellular matrix can release of these stored growth factors, allowing rapid growth factor-mediated activation of cellular activities such as cell renewal, growth, and wound healing. Over activity of MMP3 increases degradation of the extracellular matrix, resulting in loss of skin elasticity (firmness, suppleness, and skin cell renewal), increased wrinkling, and skin sagging. An insertion mutation in the promoter region of MMP3 results in increased expression of the enzyme, and over activity of MMP3.

MMP9

Matrix Metalloproteinase-9 (MMP9) is an enzyme, encoded by the gene, MMP9, that breaks down extracellular matrix proteins, particularly gelatin. Matrix metalloproteinases (MMPs) are a family of enzymes that degrade the various components of the extracellular matrix. MMP9 degrades gelatin (i.e. hydrolyzed collagen) and additionally attracts and activates neutrophils (white blood cells). MMP-9 expression is increased in response to macrophage phagocytosis. Extracellular matrix proteins are secreted by cells in order to provide structural and biochemical support to adjacent cells. The extracellular matrix regulates a cell’s dynamic behavior, serving many functions such as providing support, segregating tissues from one another, and regulating intercellular communication. Also importantly, the extracellular matrix accumulates and stores numerous cellular growth factors. Under appropriate physiological conditions, the extracellular matrix can release of these stored growth factors, allowing rapid growth factor-mediated activation of cellular activities such as cell renewal, growth, and wound healing. Overactivity of MMP9 increases degradation of the extracellular matrix, resulting in loss of skin elasticity (firmness, suppleness, and skin cell renewal), increased wrinkling, and skin sagging. A SNP in the promoter region of MMP9 results in greatly increased expression of the enzyme, and resultant damaging overactivity of MMP9 via degradation of the extracellular matrix.

Skin Hydration + Genes

AQP3

Aquaporin-3 (AQP3) is a protein, encoded by the gene AQP3, that forms pores in the membrane of biological cells through which water can flow more rapidly inside the cell than by diffusing through the membrane itself. Aquaporin-3 selectively conducts water molecules and glycerol in and out of the cell, while preventing the passage of ions and other solutes. AQP3 acts as a glycerol transporter in skin and plays an important role in regulating stratum corneum (the outermost dry layer of skin) and epidermal (underlying wet layer of skin) glycerol content, and as such is involved in skin hydration and wound healing. AQP3 expression in human skin is increased in response to skin stress. Reduced AQP3-dependent glycerol transport in AQP3-deficient epidermis appears to be responsible for reduced stratum corneum water content and elasticity (dry, stiff skin), as well as impaired wound healing and epidermal biosynthesis. These deficiencies in AQP3 can be corrected by glycerol replacement.

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Who Are You?
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Reports to let you truly know.

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